GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs1552244 | 1 | rs56394721 | chr3:10150795 | C3orf10 | chr3:10157333-10168873:+ | -0.21 | -4.44 | 1.14E-5 | Alzheimer's disease |
| THCA | cis | rs1552244 | 1 | rs56394721 | chr3:10150795 | VHL | chr3:10183319-10193744:+ | -0.2 | -4.5 | 8.62E-6 | Alzheimer's disease |
| THCA | cis | rs1075232 | 1 | rs56396205 | chr15:31678385 | CHRFAM7A | chr15:30653443-30685864:- | -0.35 | -3.5 | 0.00051 | Survival in colorectal cancer (non-distant metastatic) |
| THCA | cis | rs1075232 | 1 | rs56396205 | chr15:31678385 | FAM7A2 | chr15:30864758-30892900:+ | -0.51 | -4.54 | 7.03E-6 | Survival in colorectal cancer (non-distant metastatic) |
| THCA | cis | rs491567 | 1 | rs56396864 | chr15:53957539 | WDR72 | chr15:53805938-54051859:- | 0.16 | 3.74 | 0.000203 | Chronic kidney disease;Glomerular filtration rate (creatinine);Glomerular filtration rate in non diabetics (creatinine) |
| THCA | cis | rs13182402 | 1 | rs56397023 | chr5:125915779 | ALDH7A1 | chr5:125878918-125931082:- | 0.45 | 6.56 | 1.38E-10 | Osteoporosis |
| THCA | cis | rs8030605 | 1 | rs56398703 | chr15:56519486 | MNS1 | chr15:56720929-56757335:- | -0.24 | -3.51 | 0.000485 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs8030605 | 1 | rs56398703 | chr15:56519486 | TEX9 | chr15:56657644-56738071:+ | -0.34 | -5.81 | 1.12E-8 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs848490 | 1 | rs56400413 | chr7:77340821 | PTPN12 | chr7:77166773-77269388:+ | -0.17 | -3.97 | 8.42E-5 | Glomerular filtration rate (creatinine);Glomerular filtration rate in non diabetics (creatinine) |
| THCA | cis | rs12304921 | 1 | rs56402416 | chr12:51357791 | SLC11A2 | chr12:51373319-51422058:- | -0.24 | -4.83 | 1.87E-6 | Type 2 diabetes |
| THCA | cis | rs12304921 | 1 | rs56402416 | chr12:51357791 | TFCP2 | chr12:51488608-51566917:- | -0.2 | -4.28 | 2.25E-5 | Type 2 diabetes |
| THCA | cis | rs7216064 | 1 | rs56404791 | chr17:65893019 | C17orf58 | chr17:65987218-65989765:- | 0.24 | 4.98 | 8.83E-7 | Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma |
| THCA | cis | rs477692 | 1 | rs565974 | chr10:131423274 | MGMT | chr10:131265454-131565783:+ | 0.38 | 11.31 | 1.9E-26 | Response to temozolomide |
| THCA | cis | rs709400 | 1 | rs56660916 | chr14:104126137 | KLC1 | chr14:104029299-104167887:+ | -0.22 | -4.55 | 6.7E-6 | Body mass index |
| THCA | cis | rs9309473 | 1 | rs56672945 | chr2:73622663 | ALMS1P | chr2:73872046-73912692:+ | 0.7 | 11.05 | 1.95E-25 | Metabolite levels |